Vital Exhaustion and Biomarkers Associated With Cardiovascular Risk: The ARIC Study
Authors' conclusion
In middle-aged adults without CVD, vital exhaustion was associated with elevated hs-TnT, NT-proBNP, and hs-CRP, independent of traditional CVD risk factors.
Study context
- Population
- Middle-aged ARIC study participants without cardiovascular disease (CVD) at ARIC visit 2
- Participants
- 11,542 participants
- Exposure
- Highest vs lowest quartile of vital exhaustion
- Outcome
- Elevated hs-TnT, NT-proBNP and high-sensitivity C-reactive protein (hs-CRP) levels
Main finding
As reported in the abstract
Highest quartile vs Lowest quartileOdds ratio (95% CI)
Elevated hs-TnT
1.75(1.34–2.29)
Elevated NT-proBNP
1.40(1.19–1.64)
Elevated hs-CRP
1.14(1.01–1.28)
Observational data: associations, not effects.
Further findings
Incident CVD events and all-cause mortality (10- and 20-year follow-up) · 10 and 20 years
- Both severe vital exhaustion symptoms and elevated biomarkers associated with greater risk of CVD events and all-cause mortality
Original publication
Vital Exhaustion and Biomarkers Associated With Cardiovascular Risk: The ARIC Study. JACC Adv. Published 7 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →