Acute cardiac care & resuscitation
Association between early airway intervention in the pre-hospital setting and outcomes in out of hospital cardiac arrest patients: A post-hoc analysis of the Target Temperature Management-2 (TTM2) trial
Authors' conclusion
The choice of pre-hospital airway device was not independently associated with patient clinical outcomes.
Study context
- Population
- Adults with out-of-hospital cardiac arrest (OHCA) and return of spontaneous circulation in the TTM2 trial, with pre-hospital airway management dataof 1900 TTM2 patients
- Participants
- 1,702 adults
- Comparison
- Pre-hospital tracheal intubation (TI) vs SGA
- TIn = 1,218
- SGAn = 484reference
- Primary endpoint
- Description of pre-hospital airway management
Methodological detailspost-hoc analysis, multicentre, 13 countries
- Post-hoc analysis
- Multicentre
- 13 countries
Primary result
As reported in the abstract
Pre-hospital airway management
Further findings
Mechanically ventilated at hospital admission
P < 0.001
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| MortalityMultivariate analysis | 1.06 (0.88–1.28) | P = 0.54 | |
| 0.512Hazard ratio (log scale) |
Ventilator-free days within 26 days, 6-month neurological outcome, mortality
- TI vs SGA not independently associated with more ventilator-free days, improved neurological outcomes or decreased mortality
- Multivariate analysis
Original publication
Association between early airway intervention in the pre-hospital setting and outcomes in out of hospital cardiac arrest patients: A post-hoc analysis of the Target Temperature Management-2 (TTM2) trial. Resuscitation. Published 5 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it