Acute cardiac care & resuscitation
Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability: Prospective Multicenter Protocol-Directed Cohort Study
Authors' conclusion
Early hyperoxia exposure after resuscitation from cardiac arrest was independently associated with poor neurological function at hospital discharge.
Study context
- Population
- Adults after cardiac arrest, mechanically ventilated, receiving targeted temperature management after ROSC; trauma or sepsis causes excluded
- Participants
- 280 adults
- Exposure
- Early hyperoxia vs no hyperoxia after resuscitation
- Hyperoxian = 105
- Outcome
- Poor neurological function (modified Rankin Scale score >3)
- Follow-up
- Hospital discharge
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Hyperoxia vs No hyperoxiaAbsolute risk difference (95% CI)
Hyperoxia
12%(1–23)
Hyperoxia vs No hyperoxiaRelative risk (95% CI)
Independently associated (multivariable)
1.23(1.11–1.35)
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Poor neurological outcome per 1-hour-longer hyperoxia exposurePer 1-hour-longer duration; multivariable | 1.03 (1.02–1.05) | |
| 0.512Relative risk (log scale) |
Poor neurological outcome by alternative PaO2 cut points
- Association with poor neurological outcome began at ≥300 mm Hg
Original publication
Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability: Prospective Multicenter Protocol-Directed Cohort Study. Circulation. Published 1 February 2018. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →