Association Between Epicardial Adipose Tissue and Cardiac Dysfunction in Subjects with Severe Obesity
Authors' conclusion
Increased EAT thickness in subjects with obesity without known cardiac disease was independently associated with subclinical cardiac dysfunction.
Study context
- Population
- Subjects with BMI ≥35 kg/m² aged 35 to 65 years referred for bariatric surgery, without suspicion of or known cardiac disease
- Participants
- 186 subjects
- Exposure
- Epicardial adipose tissue (EAT) thickness tertiles
- EAT-1n = 62reference
- EAT-2n = 63
- EAT-3n = 61
- Outcome
- Association between EAT thickness and cardiac dysfunction (echocardiography and strain analyses)
Main finding
As reported in the abstract
- EAT thickness (per 1 mm increase) · global longitudinal strain (GLS) (%), independently associated decrease
- β coefficient −0.404; P = 0.002
- EAT thickness (per 1 mm increase) · LASct (%), independently associated decrease
- β coefficient −0.544; P = 0.027
- EAT-3 vs EAT-1 · cardiac dysfunction defined as GLS <18%
- OR 2.8; P = 0.013
- EAT-3 vs EAT-1 · cardiac dysfunction defined as LASct <14%
- OR 2.5; P = 0.045
Observational data: associations, not effects.
Original publication
Association Between Epicardial Adipose Tissue and Cardiac Dysfunction in Subjects with Severe Obesity. Eur J Heart Fail. Published 10 September 2023. doi:10.
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