Heart failure & cardiomyopathies
Influence of Obesity on Invasive Hemodynamics and Prognosis in Patients With Heart Failure
Authors' conclusion
In patients with HFrEF, BMI and CO correlate significantly. Symptoms and hemodynamics appear dissociated in patients with obesity. Finally, survival in patients with obesity did not differ from those without.
Study context
- Population
- Referred patients with heart failure with reduced ejection fraction (HFrEF) evaluated for advanced HF, all with right heart catheterization
- Participants
- 578 patients
- Exposure
- Obesity vs no obesity
- Obesityn = 126
- Outcome
- Associations between BMI and invasive hemodynamics; influence of obesity on clinical outcomes (death, heart transplantation, durable LV assist device implantation)
Main finding
As reported in the abstract
Cardiac output increase per 1-U increase in body mass index (BMI)
89 mL/min
Observational data: associations, not effects.
Further findings
Survival (death, heart transplantation, durable LV assist device implantation) · median follow-up 5.9 years (Q1-Q3: 2.0-10.1 years)
- Obesity did not predict survival
Symptoms vs hemodynamics
- In obesity, symptoms dissociated from filling pressures and cardiac index; clear association without obesity
Original publication
Influence of Obesity on Invasive Hemodynamics and Prognosis in Patients With Heart Failure. JACC Heart Fail. Published 19 March 2025. doi:10.
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