Acute cardiac care & resuscitation
Association between haemolysis markers and neuron-specific enolase in acute myocardial infarction complicated by cardiogenic shock patients supported with a microaxial flow pump
Authors' conclusion
Neuron-specific enolase was associated with haemolysis, and not anoxic brain injury, in AMICS patients supported with a microaxial flow pump.
Study context
- Population
- Patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) supported with a microaxial flow pump (Impella) for ≥6 hfinal study population with eligible neuron-specific enolase (NSE) and haemolysis biomarkers
- Participants
- 44 patients
- Comparison
- Patients with vs without haemolysis
- Outcome
- Peak NSE, overall
- Follow-up
- Within 72 h following microaxial flow pump placement
Methodological detailssingle tertiary Danish heart centre
- Single tertiary Danish heart centre
Main finding
As reported in the abstract
Median NSE
85 µg/L
Further findings
NSE by haemolysis · within 72 h following microaxial flow pump placement · significantly higher NSE with haemolysis
P = 0.018
NSE in out-of-hospital cardiac arrest (OHCA) vs non-OHCA patients
- Neuron-specific enolase levels were similar between OHCA and non-OHCA patients
Death from anoxic brain injury, NSE above vs below 60 µg/L
- No significant difference in death from anoxic brain injury
Correlation of NSE with haemolysis markers
- Significantly moderate correlation with all investigated haemolysis markers
Original publication
Association between haemolysis markers and neuron-specific enolase in acute myocardial infarction complicated by cardiogenic shock patients supported with a microaxial flow pump. Eur Heart J Acute Cardiovasc Care. Published 10 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →