Association Between Intensive vs Standard Blood Pressure Control and Incident Left Ventricular Conduction Disease: A Post Hoc Analysis of the SPRINT Randomized Clinical Trial
Primary result · Incident LV conduction diseaseResult — go to the resultHazard ratio 0.74 95% CI 0.56–0.98Authors' conclusion
In this study, targeting intensive BP control was associated with lower risk of left ventricular conduction disease in a randomized clinical trial
Study context
- Population
- Adults ≥50 years with hypertension and ≥1 other CV risk factor, without baseline LV conduction disease, ventricular pacing or pre-excitation; 102 sites in the US and Puerto Rico203 developed LV conduction disease
- Participants
- 3,956 vs 3,918
- Comparison
- Intensive vs standard blood pressure (BP) control
- Intensive treatmentn = 3,956
- Standard treatmentn = 3,918reference
- Primary endpoint
- Incident LV conduction disease (any fascicular or left bundle-branch block) on serial ECG
- Follow-up
- Median 3.5 years
Methodological detailspost hoc analysis, multicentre, Conducted November 2010 to August 2015; analysed November 2021 to November 2022
- Post hoc analysis
- Multicentre
- Conducted November 2010 to August 2015; analysed November 2021 to November 2022
Primary result
Incident LV conduction disease
Hazard ratio
0.74
95% CI 0.56–0.98
P = 0.04
Intensive treatmentvs Standard treatment
HR 0.74 (95% CI 0.56–0.98); P = 0.04
As reported in the abstract
Further findings
Incident RBBB (negative control)
- No association between randomization assignment and RBBB
- HR, 0.95; 95% CI, 0.71-1.27; P = .75
Factors associated with LV conduction disease
- Older age (HR per 10-year increase)
- HR, 1.42; 95% CI, 1.21-1.67; P < .001
- Male sex
- HR, 2.31; 95% CI, 1.63-3.32; P < .001
- CVD
- HR, 1.46; 95% CI, 1.06-2.00; P = .02
Original publication
Association Between Intensive vs Standard Blood Pressure Control and Incident Left Ventricular Conduction Disease: A Post Hoc Analysis of the SPRINT Randomized Clinical Trial. JAMA Cardiol. Published 1 June 2023. doi:10.
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