Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes
Main finding · Composite endpoint of incident myocardial infarction, congestive heart failure, or strokeResult — go to the resultHazard ratio 1.31 95% CI 1.25–1.38Authors' conclusion
Neighborhood-level social vulnerability was strongly associated with adverse cardiovascular outcomes and poorer BP control and may be a driver of racial disparities in hypertension. These findings highlight the potential of leveraging social vulnerability indices for tailored interventions in hypertension management.
Study context
- Population
- Large, diverse cohort of patients with hypertensionpatients with hypertension followed for a median of 6.6 years
- Participants
- 330,972 participants
- Exposure
- Association between census tract-level rankings for the social vulnerability index (SVI) with a composite endpoint of incident myocardial infarction, congestive heart failure, or stroke
- Outcome
- Composite endpoint of:
- Incident myocardial infarction
- Congestive heart failure
- Stroke
- Follow-up
- Median of 6.6 years
Methodological detailselectronic health data, census tract-level SVI rankings
- Electronic health data
- Census tract-level SVI rankings
Main finding
As reported in the abstract
Hazard ratio
1.31
95% CI 1.25–1.38
P < 0.001
Quartile 4vs quartile 1
HR 1.31 (95% CI 1.25–1.38); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Composite outcome by raceBlack racevs White raceAdjusted for SVI quartile and other clinical factors | 0.89 (0.86–0.92) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
| Outcome | Quartile 4 | Quartile 1 |
|---|---|---|
| BP control rate | 70.3% | 74.8% |
- Blood pressure (BP) control rate: significantly lower in quartile 4, P < 0.001
Racial composition of SVI quartile 4 areas
- Patients living in SVI quartile 4 areas who were Black
- 53.8%
Original publication
Association Between Neighborhood-Level Social Vulnerability and Hypertension Outcomes. JACC Adv. Published 7 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →