Association Between Physiological Significance and Vulnerable Plaque Characteristics in Patients With Myocardial Infarction: A Prospect II Substudy
Authors' conclusion
In patients with recent myocardial infarction, angiographically intermediate but physiologically significant coronary lesions were more likely to have high-risk vulnerable plaque features compared with nonphysiologically significant stenoses.
Study context
- Population
- Patients with recent MI undergoing culprit-lesion PCI plus 3-vessel NIRS-IVUS; intermediate lesions (angiographic stenosis >40%) with fractional flow reserve (FFR)/iFR319 lesions in 275 patients analysed
- Participants
- 898 patients
- Comparison
- Physiologically significant vs non-significant intermediate nonculprit lesions
- Physiologically significantn = 96
- Not significantn = 223reference
- Primary endpoint
- Association of pressure-wire physiologic indices in nonculprit lesions with vulnerable plaque characteristics
Primary result
As reported in the abstract
MLA ≤4.0 mm²
Plaque burden ≥70%
maxLCBI4mm ≥324.7
Original publication
Association Between Physiological Significance and Vulnerable Plaque Characteristics in Patients With Myocardial Infarction: A Prospect II Substudy. JACC Cardiovasc Imaging. Published 24 February 2025. doi:10.
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