Relationships of High-sensitivity C-reactive Protein (hsCRP) to High-Risk Vulnerable Plaque After NSTEMI: Insights From the PROSPECT II Trial
Authors' conclusion
Among patients with recent NSTEMI, a high baseline hsCRP level was associated with the presence of pan-coronary atherosclerosis and focal high-risk plaques.
Study context
- Population
- Patients with recent NSTEMI after treatment of all flow-limiting lesions, 3-vessel NIRS-IVUS imaging of untreated nonculprit lesions
- Participants
- 501 patients
- Comparison
- High vs intermediate vs low baseline hsCRP
- Primary endpoint
- Patients with ≥1 highly lipidic plaque (maximum lipid core burden index for any 4-mm pullback length ≥324.7)
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
≥1 highly lipidic plaque
P = 0.01
Further findings
≥1 highly lipidic plaque with ≥70% plaque burden — High vs Low · across low, intermediate and high hsCRP groups
P = 0.01
Total coronary lipid core burden index, plaque volume and odds of high-risk plaque (multivariable)
- Increasing hsCRP associated with higher total coronary artery lipid core burden index and plaque volume
- Higher hsCRP increased odds of any highly lipidic plaque and those with ≥70% plaque burden
Original publication
Relationships of hsCRP to High-Risk Vulnerable Plaque After NSTEMI: Insights From the PROSPECT II Trial. JACC Cardiovasc Interv. Published 23 April 2025. doi:10.
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