Impact of Lipidic Plaque on In-Stent and Stent Edge–Related Events After Percutaneous Coronary Intervention (PCI) in Myocardial Infarction: A PROSPECT II Substudy
Primary result · CL-MACEResult — go to the resultAdjusted odds ratio 4.11 95% CI 1.12–15.2Authors' conclusion
In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), CL stent implantation leaving behind greater stent edge-related lipid and uncovered plaque burden was associated with an increased risk of stent edge-related CL-MACE during follow-up. In contrast, CL lipid content was not related to in-stent CL-MACE.
Study context
- Population
- Patients with MI undergoing PCI of de novo culprit coronary lesions
- Participants
- 768 patients1,041 PCI-treated lesions
- Comparison
- Residual stent edge lipid with plaque burden >50% vs not
- Primary endpoint
- Culprit lesion-related major adverse cardiac events (MACE) (CL-MACE: cardiac death, MI, or unstable or progressive angina requiring revascularization or with rapid lesion progression), classified as in-stent or stent edge-related
- Follow-up
- Median 3.8 years
Methodological detailsNIRS-IVUS before and after PCI
- NIRS-IVUS before and after PCI
Primary result
CL-MACE · median 3.8 years
Adjusted odds ratio
4.11
95% CI 1.12–15.2
P = 0.03
Residual stent edge lipid (maxLCBI4mm >108.7) with plaque burden >50%vs not
adjusted OR 4.11 (95% CI 1.12–15.2); P = 0.03
As reported in the abstract
- CL-MACE events (11 stent edge-related, 13 in-stent, 1 in-lesion without a stent)
- 25
Original publication
Impact of Lipidic Plaque on In-Stent and Stent Edge–Related Events After PCI in Myocardial Infarction: A PROSPECT II Substudy. Circ Cardiovasc Interv. Published 25 September 2024. doi:10.
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