Heart failure & cardiomyopathies
Association Between Progression of Arterial Stiffness and Left Ventricular Remodeling in a Community-Based Cohort
Authors' conclusion
Longitudinal increase in arterial stiffness is associated with deterioration in LVGLS.
Study context
- Population
- Community participants without CVD and with normal arterial stiffness
- Participants
- 317 participants
- Exposure
- Longitudinal change in arterial stiffness vs change in left ventricular (LV) remodeling
- Outcome
- Association of longitudinal change in CAVI with changes in LV remodeling (LVGLS, LV mass index, e' velocity)
- Follow-up
- Median 26.8 mo
Methodological detailscommunity-based
- Community-based
Main finding
As reported in the abstract
LVGLS (impairment) per longitudinal CAVI increase
- Increase in cardio-ankle vascular index (CAVI) over follow-up
- P < 0.001
- CAVI increase associated with impaired LV global longitudinal strain (LVGLS), adjusted for demographics and baseline CV factors
- estimate 0.46 (0.11-0.82); P = 0.010 (95% CI)
- Controlling for longitudinal change of covariates
- estimate 0.50 (0.16-0.85); P = 0.004 (95% CI)
Observational data: associations, not effects.
Further findings
LVGLS deterioration with CAVI progression, sex-stratified
- Significant only in women
- estimate 0.92 (0.27-1.58); P = 0.006 (95% CI)
Original publication
Association Between Progression of Arterial Stiffness and Left Ventricular Remodeling in a Community-Based Cohort. JACC Adv. Published 5 July 2023. doi:10.
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