Heart failure & cardiomyopathies
Association Between Red Blood Cell Distribution Width-to-Albumin Ratio and Prognosis in Non-Ischaemic Heart Failure
Main finding · All-cause mortality or heart transplantation, per log2 increase of RAR (multivariable Cox)Result — go to the resultHazard ratio 2.329 95% CI 1.677–3.237Authors' conclusion
High level of RAR was an independent risk factor of poor outcome in NIHF.
Study context
- Population
- Non-ischaemic HF patients admitted to the Heart Failure Care Unit, Fuwai Hospital, December 2006 to October 2017500 reached composite outcome
- Participants
- 2,077 patients
- Exposure
- RAR and all-cause mortality or heart transplantation
- Outcome
- Composite of:
- All-cause mortality
- Heart transplantation
- Follow-up
- 1095 days
Methodological detailssingle-centre, consecutive enrolment, Follow-up for analysis set at 1095 days because gender no longer satisfied the Cox proportional risk assumption after 1150 days
- Single-centre
- Consecutive enrolment
- Follow-up for analysis set at 1095 days because gender no longer satisfied the Cox proportional risk assumption after 1150 days
Main finding
As reported in the abstract
All-cause mortality or heart transplantation, per log2 increase of RAR (multivariable Cox)
Hazard ratio
2.329
95% CI 1.677–3.237
P < 0.001
Per log2 increase of RAR
HR 2.329 (95% CI 1.677–3.237); P < 0.001
Per log2 increase of RAR, as printed
Observational data: associations, not effects.
Further findings
Incremental predictive value of adding RAR to a 12-variable traditional risk model
- Concordance index, model with RAR vs traditional model
- 0.766 (95% CI 0.754-0.778) vs. 0.758 (95% CI 0.746-0.770), P < 0.001
- Akaike information criterion
- 1487.3 vs. 1495.74
- Bayesian information criterion
- 1566.25 vs. 1569.43
- Brier score
- 1569.43 vs. 1569.43
- Likelihood ratio test
- P < 0.001
- Integrated discrimination improvement
- 1.35%, 95% CI 0.63-2.07%, P < 0.001
- Net reclassification improvement
- 13.73%, 95% CI 2.05-27.18%, P = 0.034
- Higher overall net benefit in threshold risk probability
- 20-55%
Original publication
Association Between Red Blood Cell Distribution Width-to-Albumin Ratio and Prognosis in Non-Ischaemic Heart Failure. ESC Heart Fail. Published 24 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →