Heart failure & cardiomyopathies
In-Hospital Changes in the Red Blood Cell Distribution Width and Mortality in Critically Ill Patients with Heart Failure
Authors' conclusion
Our study suggests that an increased RDW during hospitalization is independently associated with short- or long-term all-cause mortality in critical-ill patients with HF.
Study context
- Population
- Critically ill patients with heart failure (HF) (MIMIC-IV database)median age 73.91 y, 46.37% women
- Participants
- 5,514 patients
- Exposure
- In-hospital change in RDW
- Outcome
- All-cause mortality
- Follow-up
- 90 day, 180 day, and 1 year after discharge
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
All-cause mortality per 1% increase in ΔRDW (multivariable Cox)
ΔRDW (per 1% increase)Hazard ratio (95% CI)P value
90 day
1.17(1.13–1.21)
P < 0.001180 day
1.17(1.14–1.20)
P < 0.0011 year
1.18(1.15–1.20)
P < 0.001Per 1% increase, as printed
Observational data: associations, not effects.
Further findings
All-cause mortality, pre-specified subgroups
- Positive association remained consistent in pre-specified subgroups
Original publication
In-Hospital Changes in the Red Blood Cell Distribution Width and Mortality in Critically Ill Patients with Heart Failure. ESC Heart Fail. Published 6 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →