Heart failure & cardiomyopathies
Association Between Tricuspid Regurgitation and Heart Failure Outcomes: A Meta-Analysis
Pooled result · All-cause mortalityResult — go to the resultRelative risk 1.15 95% CI 1.02–1.29Authors' conclusion
Moderate and severe TR can increase the risk of all-cause mortality and HF rehospitalization rate. However, these results may be influenced by other factors. More studies on the prognosis of HF patients with different ejection fractions and regions are desired to further validate and improve our findings.
Study context
- Population
- Patients with heart failure (HF)
- Participants
- 45,829 patients12 cohort studies
- Comparison
- Tricuspid regurgitation (TR) group vs non-TR group; moderate/severe TR group vs non-TR/mild TR group
- Outcome
- All-cause mortality
Pooled result
As reported in the abstract
Relative risk
1.15
95% CI 1.02–1.29
P < 0.05
TR groupvs non-TR group
RR 1.15 (95% CI 1.02–1.29); P < 0.05
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| HF rehospitalization rateTR groupvs non-TR group | 1.24 (1.13–1.36) | P < 0.001 | |
| All-cause mortality, by severity of TR (subgroup)Moderate/severe TR groupvs non-TR/mild TR group | 1.34 (1.10–1.63) | P < 0.05 | |
| HF rehospitalization rate, by severity of TR (subgroup)Moderate/severe TR groupvs non-TR/mild TR group | 1.30 (1.16–1.45) | P < 0.001 | |
| Cardiovascular mortality, by severity of TR (subgroup)Moderate/severe TR groupvs non-TR/mild TR group | 1.49 (1.04–2.15) | P < 0.05 | |
| 0.512Relative risk (log scale) |
Subgroup analysis
- Ejection fraction, region, regression methods and publication year affected the results of both groups
Original publication
Association Between Tricuspid Regurgitation and Heart Failure Outcomes: A Meta-Analysis. ESC Heart Fail. Published 17 April 2025. doi:10.
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