Periprocedural Myocardial Injury Using Creatinine Kinase Myocardial Band (CKMB) Following Elective Percutaneous Coronary Intervention (PCI): Incidence and Associations With Long-Term Mortality
Authors' conclusion
Myocardial injury defined by elevated CKMB early after PCI is common and associated with all-cause, long-term mortality. More complex coronary anatomy is predictive of post-PCI myocardial injury.
Study context
- Population
- Adults aged ≥18 years with stable ischemic heart disease undergoing elective PCI at NYU Langone Health between 2011 and 2020, without acute myocardial infarction or elevated CKMB or troponin before PCIpatients undergoing elective PCI
- Participants
- 10,807 adults
- Exposure
- Patients with versus without post-PCI myocardial injury
- post-PCI myocardial injuryn = 1,813
- Outcome
- Incidence of post-PCI myocardial injury
Methodological detailsConsecutive adults, single centre (NYU Langone Health)
- Consecutive adults
- Single centre (NYU Langone Health)
Main finding
As reported in the abstract
Post-PCI myocardial injury
1813
16.8%
Observational data: associations, not effects.
Further findings
| Outcome | post-PCI myocardial injury | Without post-PCI myocardial injury | Hazard ratio (95% CI) | |
|---|---|---|---|---|
| All-cause mortality · 46 071 patient-years of follow-up (mean 4.3 years)Adjusted for demographics and clinical covariates | 7.9% | 3.6% | 1.46 (1.20–1.78) | |
| 0.512Hazard ratio (log scale) |
- All-cause mortality — Patients died overall
- 472 (4.4%)
- Myocardial injury by sex: female 14.1%
- Myocardial injury by sex: male 17.7%
- Myocardial injury by sex: P <0.001
- All-cause mortality: unadjusted proportions P <0.001
Factors independently associated with post-PCI myocardial injury
- Older age, longer lesion lengths, multivessel PCI, severe coronary calcification, and thrombectomy device use independently associated
Baseline characteristics
- Median age
- 67 years (interquartile range, 15.6)
- Female sex
- 24.9%
Original publication
Periprocedural Myocardial Injury Using CKMB Following Elective PCI: Incidence and Associations With Long-Term Mortality. Circ Cardiovasc Interv. Published 31 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it