Heart failure & cardiomyopathies
Association of Global Longitudinal Strain by Feature Tracking Cardiac Magnetic Resonance Imaging with Adverse Outcomes Among Community-Dwelling Adults without Cardiovascular Disease: The Dallas Heart Study
Authors' conclusion
Impaired LV GLS assessed by FT-CMR among adults free of cardiovascular disease is associated with a higher risk of incident MACE and incident HF or death independent of cardiovascular risk factors, cardiac biomarkers and LVEF.
Study context
- Population
- Community-dwelling adults with LV ejection fraction (LVEF) ≥50% without history of cardiovascular disease (CVD), Dallas Heart Study56% women, 47% Black
- Participants
- 2,234 adults
- Exposure
- Worst global longitudinal strain (GLS) quartile vs best by feature tracking CMR (FT-CMR)
- Outcome
- Incident MACE (MI, HF, hospitalization for AF, coronary revascularization, all-cause death) and incident HF or death
- Follow-up
- Median 17 years
Methodological detailscommunity-based, multivariable-adjusted Cox models
- Community-based
- Multivariable-adjusted Cox models
Main finding
As reported in the abstract
Q4 vs Q1Hazard ratio (95% CI)P value
MACE; adjusted for clinical characteristics, cardiac biomarkers, LVEF
1.55(1.07–2.24)
P = 0.02Incident HF or death; adjusted
1.57(1.03–2.38)
P = 0.04Observational data: associations, not effects.
Original publication
Association of Global Longitudinal Strain by Feature Tracking Cardiac Magnetic Resonance Imaging with Adverse Outcomes Among Community-Dwelling Adults without Cardiovascular Disease: The Dallas Heart Study. Eur J Heart Fail. Published 12 February 2024. doi:10.
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