Heart failure & cardiomyopathies
Long-term prognostic value of left and right ventricular systolic function on cardiovascular magnetic resonance imaging in systemic sclerosis
Authors' conclusion
In patients with SSc and clinically suspected cardiac disease, worse LVGLS and RVGLS on CMR were independently associated with death or MACE, while LVEF and RVEF were not.
Study context
- Population
- Adults with systemic sclerosis (SSc) who had cardiovascular magnetic resonance (CMR) imaging for suspected cardiac diseasepatients (median age 58 years, 81% women)
- Participants
- 151 adults
- Exposure
- Associations of CMR measures of LV and RV function (ejection fraction (EF) and feature tracking-derived global longitudinal strain (GLS)) with the long-term incidence of death or major adverse cardiac events (MACE)
Methodological detailsconsecutive adults
- Consecutive adults
Main finding
As reported in the abstract
Baseline CMR measures · median of 3.6 years after diagnosis
Median LVEF
58.0%
Median LVGLS
−15.7%
Median RVEF
57.0%
Median RVGLS
−16.2%
Observational data: associations, not effects.
Further findings
| Outcome | HR (per 1% worsening) (95% CI) | P value | |
|---|---|---|---|
| Composite endpoint of death or MACE, by LV function · independently associated | 1.08 (1.01–1.15) | P = 0.018 | |
| Composite endpoint of death or MACE, by RV function · independently associated | 1.08 (1.01–1.15) | P = 0.017 | |
| 0.512Hazard ratio (log scale) |
Composite endpoint of death or MACE · median follow-up of 4.7 years
- Patients experiencing the composite endpoint
- 69
Composite endpoint of death or MACE, by LV function
- LVEF was not independently associated
Composite endpoint of death or MACE, by RV function
- RVEF was not independently associated
Original publication
Long-term prognostic value of left and right ventricular systolic function on cardiovascular magnetic resonance imaging in systemic sclerosis. Eur Heart J Cardiovasc Imaging. Published 13 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it