Heart failure & cardiomyopathies
Cardiorespiratory Fitness and Risk of Heart Failure with Preserved Ejection Fraction
Main finding · Incident HFpEF by CRF categoryResult — go to the resultHazard ratio 0.48 95% CI 0.46–0.51Authors' conclusion
Higher CRF levels are independently associated with lower HFpEF in a dose-response manner. Changes in CRF reflected proportional changes in HFpEF risk, suggesting that the HFpEF risk was modulated by CRF.
Study context
- Population
- US Veterans without prior HF or MI undergoing a standardized exercise treadmill test, 1999–2020624,551 men
- Exposure
- Cardiorespiratory fitness (CRF) categories and CRF change categories
- Outcome
- Incident HFpEF
- Follow-up
- Median 10.1 years (IQR 6.0-14.3 years)
Methodological detailsmulticentre, US Veterans Affairs Medical Centers
- Multicentre
- US Veterans Affairs Medical Centers
Main finding
Incident HFpEF by CRF category
Hazard ratio
0.48
95% CI 0.46–0.51
Fitvs Least fit
HR 0.48 (95% CI 0.46–0.51)
As reported in the abstract
- Heart failure with preserved ejection fraction (HFpEF) events
- 16 493
- Average annual rate
- 2.4 events per 1000 person-years
- Being unfit: highest risk of any comorbidity
- HR 2.88 (2.67-3.11) (95% CI)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident HFpEF by CRF change (two ETTs ≥1.0 year apart)Unfit became fitvs Remained unfit37% lower risk | 0.63 (0.57–0.71) | |
| 0.512Hazard ratio (log scale) |
- Incident HFpEF by CRF change (two exercise treadmill test (ETTs) ≥1.0 year apart): n = 139 434 with two ETTs
Original publication
Cardiorespiratory Fitness and Risk of Heart Failure with Preserved Ejection Fraction. Eur J Heart Fail. Published 12 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →