Heart failure & cardiomyopathies
Genetically Predicted Androgenic Profiles and Adverse Cardiac Markers: A Sex-Specific Mendelian Randomization Study
Authors' conclusion
This study supports a causal effect of pro-androgenic sex hormone profiles in females on adverse markers of left ventricular structure and function typically associated with HF with preserved ejection fraction and with HF. There was weaker evidence of association in males.
Study context
- Population
- UK Biobank participants (genome-wide association study (GWAS) n = 425,097); UK Biobank Imaging Study (11,528 females, 14,356 males); external heart failure (HF) cohort (47,309 cases, 930,014 controls)11,528 female and 14,356 male imaging participants
- Comparison
- Genetically predicted androgenic sex hormone profiles (sex hormone-binding globulin (SHBG), total testosterone, bioavailable testosterone) and cardiac structure/function and HF
Methodological detailssex-specific, inverse-variance weighted Mendelian randomization (MR) (primary analysis)
- Sex-specific
- Inverse-variance weighted MR (primary analysis)
Main finding
As reported in the abstract
Odds ratio (CI)P value
Bioavailable testosterone (females)HF; external validation, sex-adjusted GWAS data
1.10(1.01–1.19)
P = 0.026- Bioavailable testosterone (females) · LVEDV
- β per nmol/L −0.11 (CI −0.19 to −0.03); P = 0.006
- Bioavailable testosterone (females) · LVESV
- β −0.09 (CI −0.17 to −0.01); P = 0.022
- Bioavailable testosterone (females) · LV stroke volume
- β −0.11 (CI −0.18 to −0.03); P = 0.005
- Bioavailable testosterone (females) · cardiac output
- β −0.08 (CI −0.16 to 0.00); P = 0.046
- Bioavailable testosterone (females) · cardiac index
- β −0.08 (CI −0.16 to −0.01); P = 0.034
- Total testosterone (males) · LVESV
- β −0.07 (CI −0.12 to −0.02); P = 0.007
- Bioavailable testosterone (males) · left ventricular ejection fraction (LVEF)
- β −0.11 (CI −0.18 to −0.04); P = 0.003
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Genetically Predicted Androgenic Profiles and Adverse Cardiac Markers: A Sex-Specific Mendelian Randomization Study. ESC Heart Fail. Published 22 September 2023. doi:10.
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