Arrhythmias & electrophysiology
Association of Atrial Fibrillation With Stroke and Dementia Accounting for Left Atrial Function and Size
Authors' conclusion
AF-ischemic stroke and AF-dementia associations were not statistically significant after adjusting for measures of atrial myopathy.
Study context
- Population
- ARIC participants at visit 5 (2011–2013) with echocardiographic left atrial (LA) function and size data, without prevalent stroke or dementia5,458 stroke
- Exposure
- Atrial fibrillation (AF) vs no AF, adjusted for LA function and size
- Outcome
- Ischemic stroke and dementia
- Follow-up
- 7.1 years (median)
Methodological detailstime-varying Cox regression
- Time-varying Cox regression
Main finding
As reported in the abstract
AF vs No AFHazard ratio (95% CI)
Ischemic stroke; demographic and risk factor-adjusted
1.63(1.11–2.37)
Dementia; demographic and risk factor-adjusted
1.38(1.13–1.70)
Ischemic stroke; additionally adjusted for LA reservoir strain
1.33(0.88–2.00)
Dementia; additionally adjusted for LA reservoir strain
1.15(0.92–1.43)
- Ischemic stroke events
- 209
- Dementia events
- 773
Observational data: associations, not effects.
Further findings
Ischemic stroke and dementia, adjusted for LA contractile strain, emptying fraction, minimal volume index
- Associations attenuated and not statistically significant
Original publication
Association of Atrial Fibrillation With Stroke and Dementia Accounting for Left Atrial Function and Size. JACC Adv. Published 28 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →