Association of cardiovascular diseases with cognitive performance in older adults
Authors' conclusion
Older adults with CVD had lower cognitive performance as measured than those free of CVD, driven by pronounced differences among those with CHF and those ≥80 years old with CVD.
Study context
- Population
- US older adults aged ≥60 years (NHANES)representing 55,479,673 nationally
- Participants
- 3,131 adults
- Exposure
- Older adults with cardiovascular disease (CVD) vs without CVD
- Outcome
- Cognitive performance (CERAD-IR, CERAD-DR, Animal Fluency test, DSST scores)
Methodological detailsNHANES 2011–2012 and 2013–2014 cycles
- NHANES 2011–2012 and 2013–2014 cycles
Main finding
As reported in the abstract
Cognitive test scores (lower with CVD)
CVD vs No CVDMean difference (95% CI)P value
CERAD-IR, lower with CVD
1.8(1.4–2.1)
P < 0.001CERAD-DR, lower with CVD
0.8(0.6–1.0)
P < 0.001Animal Fluency test, lower with CVD
2.1(1.6–2.6)
P < 0.001DSST, lower with CVD
9.5(8.0–10.9)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | Adjusted mean difference (95% CI) | P value | |
|---|---|---|---|
| Cognitive test scores, adjustedDSST, lower with CVD | 2.9 (1.1–4.7) | P = 0.001 | |
| −20246Difference (linear scale) |
Cognitive test scores, adjusted
- No difference in CERAD-IR, CERAD-DR and Animal Fluency test scores after adjustment
DSST by CVD subtype (subgroup)
- Congestive HF had lower DSST performance
DSST and Animal Fluency test, age ≥80 years (subgroup)
- Oldest-old (≥80 years) with CVD had lower performance than those without CVD on DSST and Animal Fluency test
Original publication
Association of cardiovascular diseases with cognitive performance in older adults. Am Heart J. Published 2 April 2024. doi:10.
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