Heart failure & cardiomyopathiesMeta-analysis
Association of Clonal Haematopoiesis with Heart Failure Incidence and Outcomes: A Systematic Review and Meta-Analysis
- Systematic review and meta-analysis
- three-level mixed-effects meta-analyses
Authors' conclusion
Clonal haematopoiesis is associated with an increased risk of incident HF and worse prognosis in individuals affected by HF.
Study context
- Population
- Individuals with and without heart failure (HF) (incident HF) and patients with established HF
- Participants
- 57,755 individuals
- Comparison
- Clonal haematopoiesis (CH) vs no CH
- Outcome
- Incidence and clinical outcomes of HF
Pooled result
New-onset HF
Hazard ratio
1.23
95% CI 1.12–1.35
P < 0.0001
CH vs Non-CH
HR 1.23 (95% CI 1.12–1.35); P < 0.0001
As reported in the abstract
Further pooled results
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality or HHF (established HF) · I2 = 0% | 1.84 (1.25–2.70) | P = 0.002 | |
| All-cause mortality (established HF) · I2 = 0% | 1.95 (1.54–2.47) | P < 0.0001 | |
| HHF (established HF) · I2 = 19% | 1.56 (1.05–2.33) | P = 0.029 | |
| 0.20.5125Hazard ratio (log scale) |
- All-cause mortality (established HF) — Increase in risk per 1% increase in variant allele fraction
- 3%
Original publication
Association of Clonal Haematopoiesis with Heart Failure Incidence and Outcomes: A Systematic Review and Meta-Analysis. Eur J Heart Fail. Published 10 March 2025. doi:10.1002/ejhf.3637
Summarised from the published abstract; every number is checked against it