Arrhythmias & electrophysiology
Association of coffee consumption and caffeine metabolism with arrhythmias and cardiac morphology: An observational, genetic, and Mendelian randomization study
Authors' conclusion
Coffee consumption was associated with a lower risk of atrial fibrillation, increased left ventricular mass, elevated ventricular volume, and larger atrial volume. Caffeine metabolism did not significantly alter the association.
Study context
- Population
- UK Biobank imaging study participants (mean age 63.5 ± 7.5 years; 52.9% female)principal imaging analysis
- Participants
- 34,992 participants
- Exposure
- Higher vs lower daily coffee consumption; caffeine metabolism
- Outcome
- Cardiac morphology (CMR) and arrhythmias by coffee consumption
Methodological detailsUK Biobank imaging study, CMR with machine learning, 2-sample Mendelian randomization
- UK Biobank imaging study
- CMR with machine learning
- 2-sample Mendelian randomization
Main finding
As reported in the abstract
Sinus rhythm with short PR interval, per cup increase: OR
0.90
95% CI 0.82–0.99
AF: OR
0.89
95% CI 0.84–0.93
Observational data: associations, not effects.
Further findings
Caffeine metabolism (CYP1A2, genetic score) and CV measurements
- Not associated with CV measurements
- P > 0.053 for all tests
Original publication
Association of coffee consumption and caffeine metabolism with arrhythmias and cardiac morphology: An observational, genetic, and Mendelian randomization study. Heart Rhythm. Published 27 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →