Heart failure & cardiomyopathies
Association of disproportionate liver fat with markers of heart failure: The multi-ethnic study of atherosclerosis
Authors' conclusion
DLF is associated with abnormal metabolic profiles and ventricular functional changes known to be associated with HFpEF
Study context
- Population
- Multi-Ethnic Study of Atherosclerosis (MESA) participants with computed tomography (CT) measurements of hepatic attenuationMESA
- Participants
- 2,932 participants
- Exposure
- Highest vs lowest quartile of disproportionate liver fat
- Outcome
- Clinical characteristics, highest vs lowest DLF quartile
Methodological detailsmultivariable linear regression
- Multivariable linear regression
Main finding
As reported in the abstract
Male
P < 0.001
Black or African American
P < 0.001
Dysglycemia
P < 0.001
| Outcome | Highest quartile of DLF | Lowest quartile of DLF |
|---|---|---|
| Triglycerides, mg/dL | 140 [98.0, 199.0] | 99.0 [72.0, 144.0] |
- Highest quartile of disproportionate liver fat (DLF) vs Lowest quartile of DLF: P > 0.001 — triglycerides (P as printed)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Cardiac function and exercise capacity (association with DLF)Highest quartile of DLF vs Lowest quartile of DLF · global longitudinal strain (lower) | −0.13 (CI −0.25 to −0.02) | P = 0.02 |
| Cardiac function and exercise capacity (association with DLF)Highest quartile of DLF vs Lowest quartile of DLF · stroke volume (lower) | −1.05 (CI −1.76 to −0.33) | P < 0.01 |
| Cardiac function and exercise capacity (association with DLF)Highest quartile of DLF vs Lowest quartile of DLF · lateral e' velocity (lower) | −0.10 (CI −0.18 to −0.02) | P = 0.02 |
| Cardiac function and exercise capacity (association with DLF)Highest quartile of DLF vs Lowest quartile of DLF · 6-minute walk distance (lower) | −4.25 (CI −7.62 to −0.88) | P = 0.01 |
Original publication
Association of disproportionate liver fat with markers of heart failure: The multi-ethnic study of atherosclerosis. Am Heart J. Published 21 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →