Heart failure & cardiomyopathies
Longitudinal comparison of dyssynchrony correction and ‘strain’ improvement by conduction system pacing: LEVEL-AT trial secondary findings
Authors' conclusion
CSP and BiVP provided similar dyssynchrony and 'strain' correction over time. Baseline global longitudinal 'strain' predicted ventricular remodelling at 12-month follow-up.
Study context
- Population
- Patients in the LEVEL-AT trial randomised to cardiac resynchronization therapy (CRT) by conduction system pacing (CSP) or biventricular pacing (BiVP)32% women
- Participants
- 69 patients
- Comparison
- CSP vs BiVP
- Primary endpoint
- Echocardiographic dyssynchrony correction and strain improvement
- Follow-up
- 1-year follow-up
Methodological detailstreatment-received analysis
- Treatment-received analysis
Primary result
As reported in the abstract
Dyssynchrony parameters and GLS · over 12 months
- Significant improvement of all dyssynchrony parameters and global longitudinal 'strain (GLS) over time, without differences between groups
- P < 0.001
Further findings
LVEF (adjusted mean) · 12 months
P = 0.31
LVESV (adjusted mean) · 12 months
P = 0.66
- Left ventricular ejection fraction (LVEF) (adjusted mean) — LVEF and LV end-systolic volume (LVESV) improved over time, without between-group differences
- P < 0.001
Baseline GLS vs 12-month LVEF and LVESV
- Baseline GLS significantly correlated with LVEF and LVESV at 12 months
Original publication
Longitudinal comparison of dyssynchrony correction and ‘strain’ improvement by conduction system pacing: LEVEL-AT trial secondary findings. Eur Heart J Cardiovasc Imaging. Published 20 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →