Cardiometabolic & kidneyCohort study
Differences in the association of lifestyle-related modifiable risk factors with incident cardiovascular disease between individuals with and without diabetes
- Retrospective cohort study
- nationwide claims database
- multivariable Cox regression
Authors' conclusion
Our analysis utilizing a nationwide epidemiological dataset presented that the relationship of lifestyle-related factors with incident CVD would be pronounced in people having diabetes
Study context
- Population
- Individuals in the JMDC Claims Database (median age 44 years, 57.5% men)173,262 (4.2%) with diabetes
- Participants
- 4,132,006 individuals
- Exposure
- Diabetes vs Non-diabetes
- Diabetesn = 173,262
- Outcome
- Incident CVD
Main finding
As reported in the abstract
Incident CVD per 1-point increase in non-ideal lifestyle-related factors
Hazard ratio (95% CI)
Non-diabetes
1.03(1.03–1.04)
Diabetes
1.09(1.07–1.11)
Per 1-point increase in non-ideal lifestyle-related factors, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident CVD for increase of lifestyle-related factors after 1-year follow-up — Non-diabetes vs Non-diabetes | 1.02 (1.01–1.04) | |
| Incident CVD for increase of lifestyle-related factors after 1-year follow-up — Diabetes vs Non-diabetes | 1.09 (1.04–1.13) | |
| 0.512Hazard ratio (log scale) |
- Incident cardiovascular disease (CVD) for increase of lifestyle-related factors after 1-year follow-up: interaction P 0.007
Original publication
Differences in the association of lifestyle-related modifiable risk factors with incident cardiovascular disease between individuals with and without diabetes. Eur J Prev Cardiol. Published 1 July 2024. doi:10.1093/eurjpc/zwae221
Summarised from the published abstract; every number is checked against it