Aortic & peripheral vascular disease
Association of HIV Infection and Incident Abdominal Aortic Aneurysm Among 143 001 Veterans
Authors' conclusion
HIV infection is associated with an increased risk of AAA among those with low CD4+ T-cell counts or elevated HIV viral load over time.
Study context
- Population
- Veterans without prevalent abdominal aortic aneurysm (AAA), Veterans Aging Cohort Study2,431 incident AAA events
- Participants
- 143,001 veterans
- Exposure
- HIV vs no HIV
- People with HIV (PWH)n = 43,766
- Outcome
- Incident AAA (ICD-9/10 or CPT codes)
- Follow-up
- Median 8.7 years
Methodological detailsmatched 1:2, Cox proportional hazards models
- Matched 1:2
- Cox proportional hazards models
Main finding
Incident AAA
Adjusted hazard ratio
1.02
95% CI 0.92–1.13
By group
PWHvs Without HIV
adjusted HR 1.02 (95% CI 0.92–1.13)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| Incident AAA by time-varying CD4+ count and HIV viral load (secondary analyses)PWH, CD4+ <200 cells/mm³vs Without HIV | 1.29 (1.02–1.65) | |
| Incident AAA by time-varying CD4+ count and HIV viral load (secondary analyses)PWH, viral load ≥500 copies/mLvs Without HIV | 1.29 (1.09–1.52) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Association of HIV Infection and Incident Abdominal Aortic Aneurysm Among 143 001 Veterans. Circulation. Published 25 May 2023. doi:10.
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