Association of Hypertensive Disorders of Pregnancy With Coronary Microvascular Dysfunction 8 to 10 Years After Delivery
Authors' conclusion
In this small study, HDP history is associated with coronary microvascular dysfunction 1 decade after delivery, findings that may, in part, be driven by metabolic factors including obesity and diabetes.
Study context
- Population
- Individuals with pregnancies delivered 2008–2010, studied by myocardial contrast echocardiography 8 to 10 years after delivery
- Participants
- 91 individuals
- Exposure
- Hypertensive disorders of pregnancy (HDP) history vs no HDP history
- HDPn = 19
- Outcome
- Coronary microvascular dysfunction (coronary flow reserve <2.0) by myocardial contrast echocardiography
- Follow-up
- 8 to 10 years after delivery
Main finding
As reported in the abstract
Proportion with HDP among those with vs without coronary microvascular dysfunction
P = 0.026
- Association of coronary flow reserve and HDP attenuated after adjusting for cardiometabolic factors
- P = 0.133
Observational data: associations, not effects.
Further findings
Microvascular dysfunction by LV remodeling (relative wall thickness >0.42) and HDP (exploratory subgroup) · exploratory subgroup analyses
- Microvascular dysfunction by left ventricular (LV) remodeling (relative wall thickness >0.42) and HDP (exploratory subgroup): P=0.0498
Original publication
Association of Hypertensive Disorders of Pregnancy With Coronary Microvascular Dysfunction 8 to 10 Years After Delivery. Circ Cardiovasc Imaging. Published 21 May 2024. doi:10.
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