Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes
Authors' conclusion
Hence, this study provides proof-of-concept evidence for the ability of MOFA to uncover multicellular immune programs in cardiovascular disease, opening new directions for mechanistic, biomarker and therapeutic studies.
Study context
- Population
- Patients with ACS or CCSplus external cohort n = 55
- Outcome
- Multicellular immune signatures identified by MOFA
Methodological detailslongitudinal, multiomic factor analysis (MOFA), external validation cohort
- Longitudinal
- Multiomic factor analysis (MOFA)
- External validation cohort
Main finding
As reported in the abstract
- Multicellular immune signatures characterized by distinct monocyte, natural killer and T cell substates and immune-communication pathways explain a large proportion of inter-patient variance
- Specific factors reflect disease state or associate with treatment outcome in ACS as measured using LVEF
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes. Nat Med. Published 21 May 2024. doi:10.
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