Heart failure & cardiomyopathies
Association of Hypoxic Burden Metrics with Cardiovascular Outcomes in Heart Failure and Sleep-Disordered Breathing
Authors' conclusion
The hypoxic burden metrics T90, TRT90, and meanSO2 , but not ODI, were independent predictors of cardiovascular death or readmission for worsening HF.
Study context
- Population
- Hospitalized heart failure (HF) patients screened for sleep-disordered breathing by polygraphy
- Participants
- 764 patients
- Exposure
- Nocturnal hypoxic burden metrics and CV outcomes
- Outcome
- Composite of:
- CV death
- Admission for worsening HF
- Follow-up
- Median 2.2 years
Main finding
As reported in the abstract
CV death or admission for worsening HF
Hazard ratio (95% CI)P value
5.0 ≤ T90 ≤ 52.0 minvs T90 < 5.0 minmultivariate Cox adjusted
1.32(1.02–1.71)
P = 0.034T90 > 52.0 minvs T90 < 5.0 minmultivariate Cox adjusted
1.56(1.21–2.02)
P = 0.001meanSO2 < 93%vs meanSO2 > 95%
1.47(1.16–1.88)
P = 0.002- Endpoint events overall
- 410 (53.7%)
Observational data: associations, not effects.
Further findings
Sleep-disordered breathing (SDB) prevalence
- Obstructive sleep apnoea
- 16.5%
- Central sleep apnoea
- 36.6%
Original publication
Association of Hypoxic Burden Metrics with Cardiovascular Outcomes in Heart Failure and Sleep-Disordered Breathing. ESC Heart Fail. Published 19 September 2023. doi:10.
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