Association of Life’s Essential 8 and Simple 7 Scores With Mortality: Comparison With Pooled Cohort Equation
Authors' conclusion
The LS7 and LE8 scores had similar risk prediction values for all-cause and cardiovascular mortality. Among 40- to 79-year-old individuals, the PCE had better risk discrimination in the LE8 and LS7 scores in predicting all-cause mortality.
Study context
- Population
- US adults, National Health and Nutrition Examination Survey cycles 2007 to 2018, linked to the National Death Index12,943 aged 40–79 years
- Participants
- 21,721 adults
- Exposure
- LE8 score vs LS7 score for mortality risk prediction
- Outcome
- Risk prediction (C-statistic) for all-cause and CV mortality
Methodological detailsnationally representative, weighted Cox models
- Nationally representative
- Weighted Cox models
Main finding
As reported in the abstract
All-cause and CV mortality, C-statistic (overall population)
| Group | C-statistic, all-cause mortality | C-statistic, CV mortality |
|---|---|---|
| LE8 | 0.823 (95% CI: 0.803-0.843) | 0.887 (95% CI: 0.857-0.905) |
| LS7 | 0.819 (95% CI: 0.799-0.838) | 0.883 (95% CI: 0.861-0.905) |
C-statistic, all-cause mortality
LE80.823 (95% CI: 0.803-0.843)
LS70.819 (95% CI: 0.799-0.838)
C-statistic, CV mortality
LE80.887 (95% CI: 0.857-0.905)
LS70.883 (95% CI: 0.861-0.905)
Observational data: associations, not effects.
Further findings
| Outcome | LE8 | LS7 | PCE |
|---|---|---|---|
| All-cause mortality, C-statistic (aged 40–79 years) | |||
| C-statistic | 0.681 (95% CI: 0.656-0.706) | 0.674 (95% CI: 0.646-0.701) | 0.756 (95% CI: 0.732-0.779) |
- All-cause mortality, C-statistic (aged 40–79 years): n = 12,943
Original publication
Association of Life’s Essential 8 and Simple 7 Scores With Mortality: Comparison With Pooled Cohort Equation. JACC Adv. Published 2 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →