Arrhythmias & electrophysiology
Association of transcatheter left atrial appendage occlusion with acute changes in left atrial pressure: An invasive hemodynamic study
Authors' conclusion
After deployment, mLAP acutely rises in 48% of patients, although this is not associated with increased HF hospitalizations. PDL is more likely to develop at 45 days in patients with significant increase in mLAP after deployment, although most leaks were small (<5 mm).
Study context
- Population
- Patients undergoing transcatheter left atrial appendage occlusion (LAAO)
- Participants
- 302 patients
- Outcome
- Change in mean left atrial pressure (mLAP) before vs after device deployment
Main finding
As reported in the abstract
mLAP increase after deployment
- Mean left atrial pressure (mLAP) increased after deployment
- 48%
- Significant mLAP increase (≥28%), among those with increase
- 38%
- Predictor of mLAP increase: baseline mLAP ≤14 mm Hg, OR
- 3.66 (2.21-6.05) (95% CI)
- Predictor of mLAP increase: nonparoxysmal AF, OR
- 1.81 (1.08-3.02) (95% CI)
- Predictor of mLAP increase: age per 5 years, OR
- 0.85 (0.73-0.99) (95% CI)
Further findings
45-day peridevice leak (PDL) with significant mLAP increase
- Significant mLAP increase independent predictor of 45-day PDL, OR
- 2.55 (1.04-6.26) (95% CI)
Safety
- No association between mLAP increase and heart failure (HF) hospitalization
Original publication
Association of transcatheter left atrial appendage occlusion with acute changes in left atrial pressure: An invasive hemodynamic study. Heart Rhythm. Published 15 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →