Arrhythmias & electrophysiology
Sex difference in atrial scar prevalence: What can we learn from the STABLE-SR-III trial?
Primary result · Recurrence, womenResult — go to the resultAdjusted hazard ratio 0.37 95% CI 0.18–0.75Authors' conclusion
In older patients with PAF, women demonstrated more advanced atrial substrate, including higher prevalence and burden of LVA compared with men. Women may receive greater benefit from additional LVA modification than men.
Study context
- Population
- Patients aged 65–80 years with paroxysmal atrial fibrillation (AF)204 (49.3%) women
- Participants
- 414 patients
- Comparison
- Circumferential pulmonary vein isolation (CPVI) plus low-voltage area (LVA) modification vs CPVI alone, by sex
- Primary endpoint
- Freedom from atrial arrhythmias after a single ablation procedure
Methodological detailssex subgroup analysis
- Sex subgroup analysis
Primary result
Recurrence, women
Adjusted hazard ratio
0.37
95% CI 0.18–0.75
By group
STABLE-SR vs CPVI alone
adjusted HR 0.37 (95% CI 0.18–0.75)
As reported in the abstract
Further findings
| Outcome | Values |
|---|---|
| LVA prevalence and burden, women vs men | Women LVA prevalence 51.5% · LVA burden 6.5% · Men LVA prevalence 32.9% · LVA burden 2.9% |
| Clinical outcomes in women by LVA status | Group 1 (CPVI + LVA modification) 90% · Group 3 (CPVI alone, no LVA) 83.8% · Group 2 (CPVI alone, with LVA) 63.6% |
- LVA prevalence and burden, women vs men: P <.001 for both
- Clinical outcomes in women by LVA status: P = .003
Original publication
Sex difference in atrial scar prevalence: What can we learn from the STABLE-SR-III trial? Heart Rhythm. Published 15 February 2024. doi:10.
Summarised from the published abstract; every number is checked against it