Heart failure & cardiomyopathies
Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy
Authors' conclusion
Baseline T-wave area has a significant association with both clinical and echocardiographic outcomes after CRT. The association of T-wave area with echocardiographic response is independent from QRS area; the association with clinical outcome, however, is not.
Study context
- Population
- Consecutive cardiac resynchronization therapy (CRT) recipients; pre-implantation T-wave and QRS area from vectorcardiograms
- Participants
- 1,355 recipients
- Exposure
- Baseline T-wave area combined with QRS area
- QRS area ≥ 109 μVs and T-wave area ≥ 66 μVsn = 616
- QRS area ≥ 109 μVs and T-wave area < 66 μVsn = 100
- Outcome
- Echocardiographic response (≥15% reduction in LV end-systolic volume) and clinical outcome (all-cause mortality, heart transplantation or LV assist device implantation)
- Follow-up
- Echocardiographic response 3–12 months after implantation
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- QRS area ≥ 109 μVs and T-wave area ≥ 66 μVs vs QRS area ≥ 109 μVs and T-wave area < 66 μVs: P = 0.004
- QRS area ≥ 109 μVs and T-wave area ≥ 66 μVs vs QRS area < 109 μVs and T-wave area ≥ 66 μVs: P < 0.001
- QRS area ≥ 109 μVs and T-wave area ≥ 66 μVs vs QRS area < 109 μVs and T-wave area < 66 μVs: P < 0.001
- QRS area ≥ 109 μVs and T-wave area ≥ 66 μVs: P < 0.001
- QRS area ≥ 109 μVs and T-wave area < 66 μVs: P < 0.001
Observational data: associations, not effects.
Further findings
Multivariate analysis including QRS area
- T-wave area associated with echocardiographic response
- P = 0.008
- T-wave area not associated with clinical outcome
- P = 0.143
Original publication
Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy. Europace. Published 26 December 2023. doi:10.
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