Heart failure & cardiomyopathies
Cardiac magnetic resonance–derived myocardial scar is associated with echocardiographic response and clinical prognosis of left bundle branch area pacing for cardiac resynchronization therapy
Authors' conclusion
Lower scar burden was associated with higher response rate of LBBAP-CRT.
Study context
- Population
- Patients with cardiac resynchronization therapy (CRT) indications who underwent cardiac magnetic resonance (CMR) and successful LBBAP-CRT
- Participants
- 54 patients
- Exposure
- CMR-derived scar burden as predictor of response to LBBAP-CRT
- Outcome
- Echocardiographic response (≥15% reduction of LV end-systolic volume)
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Prediction of echocardiographic response
| Group | AUC | +LR | -LR |
|---|---|---|---|
| Global scar % | 0.857 | 9.859 | 0.323 |
| Septal scar % | 0.864 | 5.594 | 0.233 |
| Lateral scar % | 0.822 | 3.059 | 0.175 |
| Strauss LBBB | 0.696 | 2.101 | 0.389 |
AUC
Global scar %0.857
Septal scar %0.864
Lateral scar %0.822
Strauss LBBB0.696
+LR
Global scar %9.859
Septal scar %5.594
Lateral scar %3.059
Strauss LBBB2.101
-LR
Global scar %0.323
Septal scar %0.233
Lateral scar %0.175
Strauss LBBB0.389
- Response rate with LBBAP-CRT
- 74.1%
- Non-responders had higher global, septal and lateral scar burden
- all P < 0.001
Observational data: associations, not effects.
Further findings
Composite of all-cause death or HF hospitalization · median follow-up 20.3 (11.5-38.7) months
| HR | P value | |
|---|---|---|
| Higher global scar burden | 4.996 | P's < 0.05 |
| Higher lateral scar burden | 7.019 | P's < 0.05 |
| Higher septal scar burden | 4.741 | P's < 0.05 |
Original publication
Cardiac magnetic resonance–derived myocardial scar is associated with echocardiographic response and clinical prognosis of left bundle branch area pacing for cardiac resynchronization therapy. Europace. Published 31 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →