Arrhythmias & electrophysiology
Association of Weight With Ablation Outcomes in Pediatric Wolff-Parkinson-White: Analysis of the NCDR IMPACT Registry
Authors' conclusion
Weight <30 kg was associated with a small but elevated risk of MAEs. Rates of deferred ablation and cryoablation were similar. Adjusting for factors (including accessory pathway type and location), weight <30 kg remained an independent predictor of acute success.
Study context
- Population
- Children aged 1 to 21 years with Wolff-Parkinson-White (WPW) and first-time electrophysiology study (EPS), April 2016 to December 2019, excluding congenital heart disease, cardiomyopathy and >1 ablation target
- Participants
- 4,456 children84 centers
- Exposure
- Weight <30 kg vs ≥30 kg
- Outcome
- Major adverse events (MAEs)
Methodological detailsmulticenter, IMPACT registry
- Multicenter
- IMPACT registry
Main finding
As reported in the abstract
MAEs
P = 0.04
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Ablation successAdjusted for covariates | 1.6 (1.01–2.70) | P = 0.046 | |
| 0.20.5125Odds ratio (log scale) |
- Ablation success — Success higher in the <30 kg cohort
- 95% vs 92% (P = 0.009)
Deferred ablation
- No difference in likelihood of deferred ablation
- 9% vs 12%; P = 0.07
Use of cryoablation
- No difference in use of cryoablation
- 11% vs 11%; P = 0.70
Safety
MAEs · MAEs were rare
P = 0.04
Original publication
Association of Weight With Ablation Outcomes in Pediatric Wolff-Parkinson-White: Analysis of the NCDR IMPACT Registry. JACC Clin Electrophysiol. Published 30 November 2022. doi:10.
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