Association of patient-level characteristics with long-term outcomes after Fontan palliation: Rationale, design, and baseline characteristics of the Pediatric Cardiac Care Consortium Fontan cohort study
Study context
- Population
- Patients who underwent the Fontan procedure for single ventricle congenital heart defects (CHD) between 1 and 21 years of age, in the Pediatric Cardiac Care Consortium (PCCC) registry1,366 in long-term cohort
- Participants
- 1,461 patients
- Outcome
- In-hospital Fontan failure (death or takedown) and post-discharge mortality
- Follow-up
- Through 2022
Methodological detailsrationale, design and baseline characteristics, multicentre, US registry-based, Median age at Fontan evaluation 3.1 years (IQR 2.4-4.3); males 62.1%
- Rationale, design and baseline characteristics
- Multicentre
- US registry-based
- Median age at Fontan evaluation 3.1 years (IQR 2.4-4.3); males 62.1%
Main finding
As reported in the abstract
In-hospital Fontan failure and post-discharge mortality
- In-hospital Fontan failure, n
- 95
- In-hospital deaths, n
- 78
- Fontan takedown, n
- 17
- Survived to discharge with Fontan physiology
- 1366 (93.5%)
- Post-discharge deaths, n (median follow-up 21.2 years, IQR 18.4-24.5)
- 184
Observational data: associations, not effects.
Further findings
30-year post-Fontan survival
- All Fontan types
- 75.0% (95% CI: 72.3%-77.8%)
- Lateral tunnel and extracardiac conduit
- 77.1% (95% CI: 73.5-80.8)
Original publication
Association of patient-level characteristics with long-term outcomes after Fontan palliation: Rationale, design, and baseline characteristics of the Pediatric Cardiac Care Consortium Fontan cohort study. Am Heart J. Published 26 April 2024. doi:10.
Summarised from the published abstract; every number is checked against it