Arrhythmias & electrophysiology
Associations Between Biomarkers of Myocardial Injury and Systemic Inflammation and Risk of Incident Ventricular Arrhythmia
Main finding · Incident ventricular arrhythmiaResult — go to the resultHazard ratio 1.63 95% CI 1.31–2.01Authors' conclusion
Higher concentrations of cTnT, GDF-15, IL-6, and CRP associate with HF hospitalization and death, but only cTnT predict incident VA.
Study context
- Population
- Patients treated with ICD
- Participants
- 489 patients
- Exposure
- Baseline cTnT, GDF-15, IL-6 and C-reactive protein (CRP) concentrations and incident ventricular arrhythmia
- Outcome
- ICD-detected incident ventricular arrhythmia
- Follow-up
- 3.1 ± 0.7 years
Main finding
Incident ventricular arrhythmia · 3.1 ± 0.7 years
Hazard ratio
1.63
95% CI 1.31–2.01
P < 0.001
cTnT (per log-unit)
HR 1.63 (95% CI 1.31–2.01); P < 0.001
Per log-unit, as printed
As reported in the abstract
- Patients with ≥1 ventricular arrhythmia
- 137 (28%)
Observational data: associations, not effects.
Further findings
Baseline cTnT concentration · inclusion
- Median cTnT 15 ng/L (Q1-Q3: 9-25); higher with older age, male sex, DM, CAD and heart failure (HF)
- 15
HF hospitalization and mortality
- cTnT, GDF-15, IL-6 and CRP all associated with HF hospitalization and mortality
Change in biomarkers from baseline to 1.4 years and subsequent ventricular arrhythmia
- Changes in cTnT, GDF-15, IL-6 and CRP not associated with subsequent ventricular arrhythmia
Original publication
Associations Between Biomarkers of Myocardial Injury and Systemic Inflammation and Risk of Incident Ventricular Arrhythmia. JACC Clin Electrophysiol. Published 19 June 2024. doi:10.
Summarised from the published abstract; every number is checked against it