Arrhythmias & electrophysiology
Nonlinear relationship and predictive value of systemic immune-inflammation index for atrial fibrillation recurrence after catheter ablation in hypertensive patients
Authors' conclusion
SII is a valuable marker for predicting AF recurrence postablation in hypertensive patients. It supports inflammation-based risk assessments and should be considered in clinical risk stratification. Further research is needed to explore inflammation-targeted therapies.
Study context
- Population
- Hypertensive patients with paroxysmal atrial fibrillation (AF) who underwent catheter ablation between January 2019 and January 2023
- Participants
- 418 patients
- Exposure
- Predictive performance of SII compared with that of C-reactive protein (CRP) and high-sensitivity C-reactive protein (hsCRP) for AF recurrence after catheter ablation
- Outcome
- AF recurrence
Main finding
As reported in the abstract
AF recurrence occurred
17.94%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| SII as independent predictor of recurrence | 1.13 (1.09–1.19) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
AUC
| Outcome | SII | CRP | hsCRP |
|---|---|---|---|
| ROC predictive performance | 0.688 | 0.510 | 0.542 |
- SII as independent predictor of recurrence: per-unit estimate; higher SII associated with higher risk of recurrence
Restricted cubic spline (RCS) analysis of SII and recurrence
- Nonlinear relationship; threshold above which the risk of recurrence increased markedly
- 457.41 × 109/L
Sensitivity analyses
- Sensitivity analyses confirmed the robustness of SII across subgroups
Original publication
Nonlinear relationship and predictive value of systemic immune-inflammation index for atrial fibrillation recurrence after catheter ablation in hypertensive patients. Heart Rhythm. Published 17 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it