Associations of Fitness, Physical Activity, Strength, and Genetic Risk With Cardiovascular Disease: Longitudinal Analyses in the UK Biobank Study
Authors' conclusion
Fitness and physical activity demonstrated inverse associations with incident cardiovascular disease in the general population, as well as in individuals with elevated genetic risk for these diseases.
Study context
- Population
- UK Biobank participants, stratified by genetic risk scores for CHD and AF
- Participants
- 502,635 participants
- Exposure
- Higher vs lower grip strength, physical activity and cardiorespiratory fitness, by genetic risk
- Outcome
- Incident CV events (CHD, AF) and all-cause death
- Follow-up
- Median 6.1 years (IQR 5.4-6.8)
Methodological detailsUK Biobank, stratified by genetic risk score
- UK Biobank
- Stratified by genetic risk score
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Grip strength (per SD)CHD
0.79(0.77–0.81)
Physical activity (per SD)CHD
0.95(0.93–0.97)
Cardiorespiratory fitness (per SD)CHD
0.68(0.63–0.74)
Grip strength (per SD)AF
0.75(0.73–0.76)
Physical activity (per SD)AF
0.93(0.91–0.95)
Cardiorespiratory fitness (per SD)AF
0.60(0.56–0.65)
Per SD, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CHD and AF with high cardiorespiratory fitness, high genetic risk (subgroup)High cardiorespiratory fitnessvs Lowest tertilesCHD; 49% lower risk | 0.51 (0.38–0.69) | |
| CHD and AF with high cardiorespiratory fitness, high genetic risk (subgroup)High cardiorespiratory fitnessvs Lowest tertilesAF; 60% lower risk | 0.40 (0.30–0.55) | |
| 0.20.5125Hazard ratio (log scale) |
Incident CHD and AF across genetic risk score groups (grip strength and cardiorespiratory fitness)
- Higher grip strength and cardiorespiratory fitness associated with lower risk of incident CHD and AF in each genetic risk score group
- P for trend < 0.001
- Ptrend <0.001 in each genetic risk category
Original publication
Associations of Fitness, Physical Activity, Strength, and Genetic Risk With Cardiovascular Disease: Longitudinal Analyses in the UK Biobank Study. Circulation. Published 9 April 2018. doi:10.
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