Valvular & structural heart disease
Asthma and risk of degenerative valvular heart disease: a prospective cohort study
Authors' conclusion
Asthma is independently associated with a modestly increased risk of several degenerative VHDs, particularly aortic and mitral valve diseases. These findings suggest a potential shared inflammatory pathway and highlight the need for heightened cardiovascular surveillance in individuals with asthma.
Study context
- Population
- UK Biobank participants free of valvular heart disease (VHD) at baselinefree of VHD at baseline
- Participants
- 483,735 participants
- Exposure
- Association between asthma and incident degenerative VHD
- Outcome
- Incident VHD events
- Follow-up
- Median 13.8 years
Main finding
As reported in the abstract
Aortic stenosis (AS)
5388
Aortic regurgitation (AR)
2650
Mitral regurgitation (MR)
6088
Pulmonary regurgitation (PR)
821
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| AS | 1.31 (1.21–1.41) | |
| ARAsthmavs No asthma | 1.24 (1.11–1.39) | |
| ARAsthmavs No asthmaAfter adjusting for asthma medications | 1.12 (0.97–1.30) | |
| MR | 1.19 (1.10–1.28) | |
| PR | 1.34 (1.10–1.62) | |
| 0.512Hazard ratio (log scale) |
Sensitivity analyses
- Results were robust across multiple sensitivity analyses, including adjustment for asthma duration and exclusion of participants with pre-existing cardiovascular disease
Original publication
Asthma and risk of degenerative valvular heart disease: a prospective cohort study. Heart. Published 19 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →