Atlas of gut microbe-derived products from aromatic amino acids and risk of cardiovascular morbidity and mortality
Authors' conclusion
Key gut microbiota-generated metabolites derived from aromatic amino acids independently associated with incident adverse cardiovascular outcomes are identified
Study context
- Population
- Sequential subjects undergoing elective diagnostic cardiac evaluationtwo independent cohorts
- Participants
- 4,000 vs 833
- Exposure
- US vs EU
- USn = 4,000
- EUn = 833
- Outcome
- Incident MACE (MI, stroke or death) and all-cause mortality
- Follow-up
- 3-year
Methodological detailstwo independent cohorts, stable isotope dilution mass spectrometry, Metabolites also measured in plasma from humans and mice before vs after poorly absorbed antibiotics to suppress gut microbiota
- Two independent cohorts
- Stable isotope dilution mass spectrometry
- Metabolites also measured in plasma from humans and mice before vs after poorly absorbed antibiotics to suppress gut microbiota
Main finding
As reported in the abstract
- Multiple aromatic amino acid-derived metabolites originating at least in part from gut bacteria associated with incident major adverse cardiovascular event (MACE) and all-cause mortality, independent of traditional risk factors
- Phenylacetyl glutamine and phenylacetyl glycine (from phenylalanine) associated with incident MACE and poorer survival
- P-cresol (from tyrosine), yielding p-cresol sulfate and p-cresol glucuronide, associated with incident MACE and poorer survival
- 4-OH-phenyllactic acid (from tyrosine), yielding 4-OH-benzoic acid and 4-OH-hippuric acid, associated with incident MACE and poorer survival
- Indole (from tryptophan), yielding indole glucuronide and indoxyl sulfate, associated with incident MACE and poorer survival
- Indole-3-pyruvic acid (from tryptophan), yielding indole-3-lactic acid and indole-3-acetyl-glutamine, associated with incident MACE and poorer survival
- 5-OH-indole-3-acetic acid (from tryptophan) associated with incident MACE and poorer survival
- Independent of traditional risk factors
Observational data: associations, not effects.
Original publication
Atlas of gut microbe-derived products from aromatic amino acids and risk of cardiovascular morbidity and mortality. Eur Heart J. Published 21 June 2023. doi:10.
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