Arrhythmias & electrophysiology
Atrial Abnormalities in Brugada Syndrome: Evaluation With ECG Imaging
Authors' conclusion
ECGI-calculated TACT and LACT are significantly prolonged in BrS patients compared with control patients, and in BrS patients after AJM.
Study context
- Population
- Consecutive patients with Brugada syndrome in a monocentric registry, with electrocardiogram imaging (ECGI) before and after ajmaline
- Participants
- 43 vs 40
- Exposure
- Brugada syndrome (BrS) patients vs controls; before vs after ajmaline
- BrSn = 43
- Controln = 40reference
- Outcome
- Atrial tachyarrhythmias during follow-up
- Follow-up
- Mean 40.9 months
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
First ATa occurrence during follow-up
BrS
13.9%
6 of 43
- Total atrial conduction time (TACT) the only independent predictor of atrial tachyarrhythmias (ATas); cutoff >138.5 ms
- sensitivity 0.92 [95% CI: 0.83-0.98], specificity 0.70 [95% CI: 0.59-0.81]
Observational data: associations, not effects.
Further findings
TACT and local atrial conduction time (LACT) (ECGI)
- TACT and LACT significantly prolonged in BrS vs controls
- TACT and LACT significantly higher after ajmaline (AJM) and in carriers of a pathogenic/likely pathogenic SCN5A variant
Original publication
Atrial Abnormalities in Brugada Syndrome: Evaluation With ECG Imaging. JACC Clin Electrophysiol. Published 9 August 2023. doi:10.
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