Arrhythmias & electrophysiology
Atrial Fibrillation Recurrence After Left Atrial Appendage Occlusion in Patients Undergoing Ablation: The OPTION Trial Sub analysis
Authors' conclusion
Among patients undergoing AF ablation, LAAC (concomitant or sequential) does not affect AF ablation outcomes. The stroke/systemic embolism rate was low in all groups.
Study context
- Population
- Patients undergoing atrial fibrillation (AF) ablation in the OPTION trial
- Participants
- 1,600 patients
- Comparison
- Left atrial appendage closure (LAAC) vs anticoagulation after AF ablation
- LAACn = 803
- Anticoagulationn = 797reference
- Primary endpoint
- AF recurrence
Primary result
As reported in the abstract
36-month follow-up
P = 0.08
Secondary outcomes
Sequential LAAC vs Concomitant LAAC
AF recurrence, sequential vs concomitant LAAC (subgroup)
P = 0.83
AF recurrence vs No AF
Stroke or systemic embolism, by AF recurrence · after 12 months of follow-up
P = 0.57
Original publication
Atrial Fibrillation Recurrence After Left Atrial Appendage Occlusion in Patients Undergoing Ablation: The OPTION Trial Sub analysis. JACC Clin Electrophysiol. Published 7 November 2025. doi:10.
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