Attributable mortality benefit of digoxin treatment in hypoplastic left heart syndrome after the Norwood operation: An instrumental variable-based analysis using data from the Pediatric Health Information Systems Database
Authors' conclusion
In this observational study of patients with HLHS after Norwood using instrumental variable techniques, a significant benefit in 1-year transplant-free survival attributable to digoxin was demonstrated.
Study context
- Population
- Neonates with hypoplastic left heart syndrome (HLHS) born 2007–2021 who underwent Norwood operation at Pediatric Health Information Systems Database hospitals and survived >14 days after operation
- Participants
- 5,148 neonates · 47 hospitals
- Exposure
- Digoxin vs no digoxin after Norwood operation
- Digoxinn = 2,184
- Outcome
- Transplant-free survival
- Follow-up
- 1 year
Methodological detailsinstrumental variable analysis, multicentre
- Instrumental variable analysis
- Multicentre
Main finding
1-year transplant-free survival
Odds ratio
0.71
95% CI 0.54–0.94
P = 0.01
By group
Digoxin vs No digoxin
OR 0.71 (95% CI 0.54–0.94); P = 0.01
As reported in the abstract
- Absolute risk reduction
- 5%
- NNT
- 20
Observational data: associations, not effects.
Original publication
Attributable mortality benefit of digoxin treatment in hypoplastic left heart syndrome after the Norwood operation: An instrumental variable-based analysis using data from the Pediatric Health Information Systems Database. Am Heart J. Published 10 May 2023. doi:10.
Summarised from the published abstract; every number is checked against it