Heart failure & cardiomyopathiesCohort study
Autoimmune Disorders in Heart Failure With Preserved Ejection Fraction
- Observational cohort study
- consecutively evaluated patients
Authors' conclusion
Patients with HFpEF and autoimmune disorders have similar hemodynamic derangements but greater peripheral deficits in oxygen transport and higher risk for adverse outcome compared with those without.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) diagnosed by invasive cardiopulmonary hemodynamic exercise testing79 (8.0%) with autoimmune disorders
- Participants
- 982 patients
- Exposure
- HFpEF with vs without autoimmune disorders
- Autoimmune disordersn = 79
- Outcome
- Death or heart failure (HF) hospitalization
- Follow-up
- Median 3.0 years
Main finding
As reported in the abstract
Hazard ratio
1.95
95% CI 1.17–3.27
P = 0.011
Autoimmune disorders vs Without autoimmune disorders
HR 1.95 (95% CI 1.17–3.27); P = 0.011
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| HF hospitalization | 2.87 (1.09–7.57) | P = 0.033 | |
| 0.10.31310Hazard ratio (log scale) |
Arterial-venous oxygen content difference at rest
P < 0.001
Arterial-venous oxygen content difference during exercise
P < 0.001
| Outcome | Autoimmune disorders | Without autoimmune disorders | Estimate | P value |
|---|---|---|---|---|
| VE/VCo2 slope | 38.0 (SD 7.9) | 36.2 (SD 7.3) | P = 0.043 |
- Prevalence of autoimmune disorders in HFpEF
- 8.0% · 79 of 79
Hemodynamics at rest and exercise
- Did not differ between the groups
Factors associated with autoimmune disorders
- Female sex, higher heart rate, lower hemoglobin, absence of AF and absence of CAD independently associated
Original publication
Autoimmune Disorders in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. Published 29 May 2024. doi:10.1016/j.jchf.2024.04.016
Summarised from the published abstract; every number is checked against it