Azithromycin Exposure in a 10-Day Window of Myocardial Infarction and Short- and Long-Term Outcomes
Main finding · Subsequent MIResult — go to the resultHazard ratio 1.41 95% CI 1.10–1.81Authors' conclusion
We found an increased risk of long-term subsequent MI, 30-day hospital readmissions, and 30-day incident HF among MI patients with AZM exposure compared to controls.
Study context
- Population
- Adult inpatients admitted with myocardial infarction (MI), Merative MarketScan databases, 2010–2017Heart failure (HF)-free cohort 9,180
- Participants
- 18,066 inpatients
- Exposure
- Azithromycin (AZM) exposure vs no AZM exposure around MI
- AZMn = 3,011
- Outcome
- Subsequent MI
- Follow-up
- Up to 5 years post-MI
Main finding
As reported in the abstract
Hazard ratio
1.41
95% CI 1.10–1.81
P = 0.0076
By group
AZMvs Control
HR 1.41 (95% CI 1.10–1.81); P = 0.0076
Observational data: associations, not effects.
Further findings
| Outcome | AZM | Control | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Incident HF (HF-free at baseline cohort) · up to 5 years post-MI | 39.8% | 35.5% | 1.12 (0.91–1.39) | P = 0.2795 | |
| 0.512Hazard ratio (log scale) |
- Incident HF (HF-free at baseline cohort): HF-free cohort AZM n = 1,530
All-cause, MI-related, MI and sequelae-related readmissions and incident HF · 30 days post-MI
- Odds of all 4 30-day outcomes significantly higher with AZM vs control
Original publication
Azithromycin Exposure in a 10-Day Window of Myocardial Infarction and Short- and Long-Term Outcomes. JACC Adv. Published 18 October 2024. doi:10.
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