Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort
Authors' conclusion
In the MESA cohort, higher baseline levels of hs-cTnT and NT-proBNP predicted an increased risk of incident cancer, with no significant differences by race/ethnicity or sex.
Study context
- Population
- MESA participants free of self-reported cancer and cardiovascular disease at baselineMESA participants free of self-reported cancer and cardiovascular disease at baseline
- Participants
- 6,244 participants
- Exposure
- Association of baseline high-sensitivity cardiac troponin T (hs-cTnT) and NT-proBNP levels with incident cancer risk
- Outcome
- Incident cancer events
- Follow-up
- Median 17.8 years
Main finding
As reported in the abstract
Incident cancer events
820
Incidence rate
91.2 cases per 10,000 person-years
Observational data: associations, not effects.
Further findings
| Outcome | HR (per SD) (95% CI) | P value | |
|---|---|---|---|
| All-cancer endpointshs-cTnT · fully adjusted model | 1.18 (1.09–1.27) | P < 0.001 | |
| All-cancer endpointsNT-proBNP · fully adjusted model | 2.41 (1.30–4.49) | P = 0.006 | |
| 0.20.5125Hazard ratio (log scale) |
- All-cancer endpoints: HRs calculated based on the SDs for continuous covariates after standardization
Incidence rates for all cancers by baseline hs-cTnT and NT-proBNP levels
- Higher incidence rates for all cancers generally associated with higher baseline hs-cTnT and NT-proBNP levels, especially in the highest quartiles
Effect modification by sex and race/ethnicity
- Sex and race/ethnicity did not significantly affect any of these associations
Baseline characteristics
- Median age
- 61.0 years
- Female
- 52.7%
Original publication
Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort. JACC Adv. Published 16 June 2025. doi:10.
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