Baseline Cardiac Parameters as Biomarkers of Radiation Cardiotoxicity in Lung Cancer: An NI-HEART Analysis
Authors' conclusion
The present findings suggest that cardiac history and RT planning scan parameters may offer potential utility in prospectively evaluating cardiotoxicity risk following RT for patients with lung cancer.
Study context
- Population
- Patients who underwent definitive radiation therapy (RT) for non-small cell lung cancer with modern planning techniques, 2015–2020
- Participants
- 478 patients
- Outcome
- MACE and mortality after RT (predictive value of clinical and imaging-based cardiac parameters)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
MACE
Patients developing major adverse cardiac events (MACE) (88 events)
77
16%
Median time to event
16.3 months
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Atrial arrhythmia, by left atrial enlargement on RT planning scans · 5 yearsLeft atrial enlargement vs No enlargement · 14% [95% CI: 9%-20%] vs 4% [95% CI: 2%-8%] | P = 0.001 |
| HF, by LV enlargement on RT planning scans · 5 yearsLV enlargement vs No enlargement · 13% [95% CI: 8%-18%] vs 6% [95% CI: 3%-10%] | P = 0.007 |
| MI, by coronary calciumCoronary calcium vs No coronary calcium · 4.2% [95% CI: 2%-7%] vs 0% [95% CI: 0%-0%]; not associated | P = 0.094 |
Survival
- No cardiac imaging metrics both clinically and statistically associated with survival
Original publication
Baseline Cardiac Parameters as Biomarkers of Radiation Cardiotoxicity in Lung Cancer: An NI-HEART Analysis. JACC CardioOncol. Published 2 July 2024. doi:10.
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